JUST IN: Massive bets as bills set to knock the cardinals back down the ladder a bit..

In Week 1 of the 2024 NFL season, the Buffalo Bills are set to take on the Arizona Cardinals, marking their first encounter since the 2020 NFL season. Despite the kickoff being 111 days away, DraftKings has already released opening odds for all 32 NFL teams, with the Bills opening as seven-point favorites for their home opener against the Cardinals.

According to the current odds, betting $10 on the Bills to beat the Cardinals would yield $12.82 if successful, while a win by exactly seven points would result in a payout of $18.33. Conversely, wagering on the Cardinals to win would bring in $38 if successful, with a $20 payout for a loss by less than seven points.

The over/under for the game is set at 48 points, with the moneyline favoring the Bills at -355 and the Cardinals at +255.

Reflecting on the previous season, the Bills concluded with the fifth-best record in the league at 11-6, boasting a formidable offense, a stout defense, and a competent special teams unit. Meanwhile, the Cardinals struggled, finishing near the bottom with a 4-13 record and ranking lower in offensive, defensive, and special teams categories.

Dating back to 1971, Buffalo holds a 7-5 overall record against the Cardinals, with their encounters being infrequent due to their status as teams from opposing conferences.

Although the rosters have undergone significant changes since their last meeting in 2020, characterized by memorable moments such as the “Hail Murray,” anticipation remains high for their upcoming clash in Week 1 of the 2024 season. Despite uncertainties surrounding roster dynamics, expectations are high for both teams, particularly for star quarterbacks Josh Allen and Kyler Murray to deliver a thrilling performance.

As the countdown to Week 1 continues, speculation abounds regarding the outcome of this matchup, with Vegas favoring the Bills to emerge victorious. However, only time will tell if these predictions hold true when the teams finally meet on the field.